Basic Electrophysiology

Basic Electrophysiology

The electrophysiological studies are crucial in the investigation of diseases in which a genetic defect resulting in abnormal functioning of the electrical properties of the heart. In such disorders, genes are studied genes encoding ion channels or other proteins related to the function of these. The mutations detected by screening specific breed in heterologous systems to be able to study possible alterations in the function of ion channels.

The study of changes in the electrical properties of these channels, caused by mutations provides information essential to confirm the diagnosis and for making decisions about the treatment of patients with the inherited disease. Electrophysiological studies are often combined with studies in animal models to investigate how the mutation affects the heart's electrical balance and predisposes to arrhythmias.

The electrophysiological studies of ion channels is also performed in cultured primary myocytes in humans and other mammals.

Cardiovascular Genetics Center
IDIBGI C/ Dr Castany s/n, Parc Hospitalari Martí i Julià (M-2) 17290, Salt, Girona . Tel: 872 987087 · gencardio.diagnostics@gencardio.com