INTRACELLULAR TRAFFIC AND LOCALIZATION OF ION CHANNELS

INTRACELLULAR TRAFFIC AND LOCALIZATION OF ION CHANNELS

We investigate the mechanisms regulating subcellular localization of Nav1.5, the pore-forming subunit of the cardiac sodium channel. Using as a model cardiomyocytes cell lines (H9c2, and P19 HL-1) and immortalized lines (HEK 293T, HeLa and MDCK). Under heterologous gene expression in these cells, we try to characterize the intracellular trafficking of Nav1.5, evaluate the role of specific regions of Nav1.5 potentially involved in the regulation of their trafficking and localization subcellular, and study the effect of changes in traffic Nav1.5 protein regions where known family mutations associated with heart disease.

Cardiovascular Genetics Center
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